Sorry, Republicans. You put up a good fight there, with your....well, ok, you put up a shitty fight, with your death panels and your townhall disruptions and your childish disruptionism (epitomized so perfectly by this joker tonight).
But you played the hand you were dealt: you couldn't defend the current indefensible system that sends thousands of people to their unnecessary deaths every year. And you couldn't endorse the Democratic proposals in the House and Senate, because you'd be handing the Democrats a victory they'd spend the next two decades beating you over the head with. The only way you could win, politically, would be if nothing passed, or at least nothing very big. So, you threw every turd you had against the wall, hoping some of it would splatter far enough when it hit that it'd cover some Democrats, and that the resulting chaos would somehow keep the Dems from passing important legislation that would help America.
Well, it didn't work, and President Obama's speech tonight (God, I'll never get tired of typing those words) just made your victory impossible. Now, all you can do is fight over the details, but you've lost the big game: as Obama mentioned, about 80% of the proposed reform is uncontroversial and will have no trouble passing through Congress. The remaining 20% was just explained and defended very well by a charismatic media rock-star President, and you looked like 218 childish, petulant (white, male) teenagers who were mad that Dad wasn't letting you drive the Mercedes anymore.
Have fun in the political wilderness you spent the last decade working so hard to earn for yourselves. Come back when you have some big-boy and big-girl ideas about how to fix the country.